2qt7

X-ray diffraction
1.3Å resolution

Crystallographic structure of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase IA-2 at 1.30 Angstroms

Released:
Model geometry
Fit model/data

Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assemblies composition:
homo tetramer
homo dimer (preferred)
PDBe Complex ID:
PDB-CPX-172595 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ICA512-transmembrane fragment Chains: A, B
Molecule details ›
Chains: A, B
Length: 91 amino acids
Theoretical weight: 9.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16849 (Residues: 468-558; Coverage: 10%)
Gene names: ICA3, ICA512, PTPRN
Sequence domains: Protein-tyrosine phosphatase receptor IA-2
Structure domains: Protein-tyrosine phosphatase receptor IA-2 ectodomain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P212121
Unit cell:
a: 31.756Å b: 66.799Å c: 73.131Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.22 0.242
Expression system: Escherichia coli