› 2qtj

X-ray solution scattering

Solution structure of human dimeric immunoglobulin A

Released:
DOI: 10.2210/pdb2qtj/pdb
PDB entry 2qtj coloured by chain, ensemble of 10 models, front view.
PDB entry 2qtj coloured by chain, ensemble of 10 models, side view.
PDB entry 2qtj coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Implications of the near-planar solution structure of human myeloma dimeric IgA1 for mucosal immunity and IgA nephropathy.
Bonner A, Furtado PB, Almogren A, Kerr MA, Perkins SJ
J Immunol 180 1008-18 (2008)
PMID: 18178841

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212386 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Kappa light chain IgA1 Chains: L, M, N, O
Molecule details ›
Chains: L, M, N, O
Length: 214 amino acids
Theoretical weight: 23.22 KDa
Source organism: Homo sapiens
Ig-like domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 475 amino acids
Theoretical weight: 51.07 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q6MZW0 (Residues: 37-41, 42-135, 136-138, 139-506; Coverage: 100%)
Gene name: DKFZp686J11235
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Quick links

Citations

6 review citations

Are anti-HIV IgAs good guys or bad guys?
Zhou et al. (2014)
5 more

6 mentions without citation

IgA and FcαRI: Pathological Roles and Therapeutic Opportunities.
Breedveld et al. (2019)
5 more