› 2qts

X-ray diffraction
1.9Å resolution

Structure of an acid-sensing ion channel 1 at 1.9 A resolution and low pH

Released:
DOI: 10.2210/pdb2qts/pdb
PDB entry 2qts coloured by chain, front view.
PDB entry 2qts coloured by chain, side view.
PDB entry 2qts coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH.
Jasti J, Furukawa H, Gonzales EB, Gouaux E
Nature 449 316-23 (2007)
PMID: 17882215

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173089 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Acid-sensing ion channel 1 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 438 amino acids
Theoretical weight: 50.15 KDa
Source organism: Gallus gallus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q1XA76 (Residues: 26-463; Coverage: 83%)
Gene names: ACCN2, ASIC1
Sequence domains: Amiloride-sensitive sodium channel
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
Carbohydrate polymer
2 bound ligands:
Ligand NAG 12 x NAG
Ligand CL 6 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P21
Unit cell:
a: 124.252Å b: 110.781Å c: 149.891Å
α: 90° β: 97.54° γ: 90°
R-values:
R R work R free
0.21 0.208 0.233
Expression system: Spodoptera frugiperda

Quick links

Citations

156 review citations

pH sensing and regulation in cancer.
Damaghi et al. (2013)
155 more

58 mentions without citation

Influences of membrane mimetic environments on membrane protein structures.
Zhou et al. (2013)
57 more