› 2quo

X-ray diffraction
1.75Å resolution

Crystal Structure of C terminal fragment of Clostridium perfringens enterotoxin

Released:
DOI: 10.2210/pdb2quo/pdb
PDB entry 2quo coloured by chain, front view.
PDB entry 2quo coloured by chain, side view.
PDB entry 2quo coloured by chain, top view.
Source organism: Clostridium perfringens
Primary publication:
Structure of the claudin-binding domain of Clostridium perfringens enterotoxin.
Van Itallie CM, Betts L, Smedley JG, McClane BA, Anderson JM
J Biol Chem 283 268-274 (2008)
PMID: 17977833

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134385 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heat-labile enterotoxin B chain Chain: A
Molecule details ›
Chain: A
Length: 126 amino acids
Theoretical weight: 14.27 KDa
Source organism: Clostridium perfringens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01558 (Residues: 194-319; Coverage: 40%)
Gene name: cpe
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P212121
Unit cell:
a: 37.626Å b: 49.041Å c: 69.078Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.197 0.229
Expression system: Escherichia coli

Quick links

Citations

21 review citations

Claudins and the modulation of tight junction permeability.
Günzel et al. (2013)
20 more

11 mentions without citation

On the interaction of Clostridium perfringens enterotoxin with claudins.
Veshnyakova et al. (2010)
10 more