› 2qyp

X-ray diffraction
2.45Å resolution

Orthorhombic Crystal Structure of Human Saposin C Dimer in Open Conformation

Released:
DOI: 10.2210/pdb2qyp/pdb
PDB entry 2qyp coloured by chain, front view.
PDB entry 2qyp coloured by chain, side view.
PDB entry 2qyp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of human saposins C andD: implications for lipid recognition and membrane interactions.
Rossmann M, Schultz-Heienbrok R, Behlke J, Remmel N, Alings C, Sandhoff K, Saenger W, Maier T
Structure 16 809-17 (2008)
PMID: 18462685

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139657 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Saposin-C Chains: A, B
Molecule details ›
Chains: A, B
Length: 91 amino acids
Theoretical weight: 10.38 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P07602 (Residues: 311-392; Coverage: 16%)
Gene names: GLBA, PSAP, SAP1
Sequence domains:
Structure domains: Saposin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR571
Spacegroup: C2221
Unit cell:
a: 57.008Å b: 88.904Å c: 93.465Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.229 0.29
Expression system: Komagataella pastoris

Quick links

Citations

15 review citations

Lysosomal degradation of membrane lipids.
Kolter et al. (2010)
14 more

11 mentions without citation

Structure and mechanism of the saposin-like domain of a plant aspartic protease.
Bryksa et al. (2011)
10 more