› 2r2h

X-ray diffraction
2Å resolution

Structure of S25-2 in Complex with Ko

Released:
DOI: 10.2210/pdb2r2h/pdb
PDB entry 2r2h coloured by chain, front view.
PDB entry 2r2h coloured by chain, side view.
PDB entry 2r2h coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Exploration of specificity in germline monoclonal antibody recognition of a range of natural and synthetic epitopes.
Brooks CL, Müller-Loennies S, Brade L, Kosma P, Hirama T, MacKenzie CR, Brade H, Evans SV
J Mol Biol 377 450-68 (2008)
PMID: 18272175

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-176020 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 219 amino acids
Theoretical weight: 24.24 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q52L64 (Residues: 21-240; Coverage: 100%)
Gene names: Gm10883, Igkv8-30
Sequence domains:
Structure domains: Immunoglobulins
Ig-like domain-containing protein Chain: B
Molecule details ›
Chain: B
Length: 222 amino acids
Theoretical weight: 24.11 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q6PIP8 (Residues: 20-122, 123-234; Coverage: 48%)
Gene name: Igh
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:
Ligand MG 1 x MG
Ligand KO2 1 x KO2
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 45.8Å b: 81.3Å c: 132.35Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.215 0.262

Quick links

Citations

3 review citations

Grading the commercial optical biosensor literature-Class of 2008: 'The Mighty Binders'.
Rich et al. (2010)
2 more