› 2r37

X-ray diffraction
1.85Å resolution

Crystal structure of human glutathione peroxidase 3 (selenocysteine to glycine mutant)

Released:
DOI: 10.2210/pdb2r37/pdb
PDB entry 2r37 coloured by chain, front view.
PDB entry 2r37 coloured by chain, side view.
PDB entry 2r37 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Pilka ES, Guo K, Gileadi O, Rojkowa A, von Delft F, Pike ACW, Kavanagh KL, Johannson C, Sundstrom M, Arrowsmith CH, Weigelt J, Edwards AM, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-149602 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione peroxidase 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 207 amino acids
Theoretical weight: 23.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P22352 (Residues: 25-223; Coverage: 97%)
Gene names: GPX3, GPXP
Sequence domains: Glutathione peroxidase
Structure domains: Glutaredoxin

Ligands and Environments

2 bound ligands:
Ligand CL 2 x CL
Ligand NA 2 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21212
Unit cell:
a: 103.72Å b: 61.308Å c: 100.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.153 0.151 0.183
Expression system: Escherichia coli

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