› 2r55

X-ray diffraction
2.5Å resolution

Human StAR-related lipid transfer protein 5

Released:
DOI: 10.2210/pdb2r55/pdb
PDB entry 2r55 coloured by chain, front view.
PDB entry 2r55 coloured by chain, side view.
PDB entry 2r55 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Comparative structural analysis of lipid binding START domains.
Thorsell AG, Lee WH, Persson C, Siponen MI, Nilsson M, Busam RD, Kotenyova T, Schüler H, Lehtiö L
PLoS One 6 e19521 (2011)
PMID: 21738568

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192597 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
StAR-related lipid transfer protein 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 231 amino acids
Theoretical weight: 25.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NSY2 (Residues: 6-213; Coverage: 98%)
Gene name: STARD5
Sequence domains: START domain
Structure domains: Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P65
Unit cell:
a: 62.87Å b: 62.87Å c: 214.93Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.236 0.232 0.276
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

16 review citations

Early steps in steroidogenesis: intracellular cholesterol trafficking.
Miller et al. (2011)
15 more

13 mentions without citation

The StarD4 subfamily of steroidogenic acute regulatory-related lipid transfer (START) domain proteins: new players in cholesterol metabolism.
Calderon-Dominguez et al. (2014)
12 more