› 2r5j

X-ray diffraction
3.3Å resolution

Pentamer Structure of Major Capsid protein L1 of Human Papilloma Virus Type 35

Released:
DOI: 10.2210/pdb2r5j/pdb
PDB entry 2r5j coloured by chain, front view.
PDB entry 2r5j coloured by chain, side view.
PDB entry 2r5j coloured by chain, top view.
Source organism: human papillomavirus 35
Primary publication:
Crystal structures of four types of human papillomavirus L1 capsid proteins: understanding the specificity of neutralizing monoclonal antibodies.
Bishop B, Dasgupta J, Klein M, Garcea RL, Christensen ND, Zhao R, Chen XS
J Biol Chem 282 31803-11 (2007)
PMID: 17804402

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150954 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Major capsid protein L1 Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O
Length: 423 amino acids
Theoretical weight: 47.23 KDa
Source organism: human papillomavirus 35
Expression system: Escherichia coli
UniProt:
  • Canonical: P27232 (Residues: 21-401, 437-472; Coverage: 83%)
Gene name: L1
Sequence domains: L1 (late) protein
Structure domains: Major capsid L1 (late) superfamily, Papillomavirus

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P21
Unit cell:
a: 150.41Å b: 176.606Å c: 197.073Å
α: 90° β: 92.11° γ: 90°
R-values:
R R work R free
0.317 0.315 0.348
Expression system: Escherichia coli

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Citations

18 review citations

Nuclear import by karyopherin-βs: recognition and inhibition.
Chook et al. (2011)
17 more

4 mentions without citation

Identification of neutralizing conformational epitopes on the human papillomavirus type 31 major capsid protein and functional implications.
Fleury et al. (2009)
3 more