› 2r5k

X-ray diffraction
3.2Å resolution

Pentamer Structure of Major Capsid protein L1 of Human Papilloma Virus type 11

Released:
DOI: 10.2210/pdb2r5k/pdb
PDB entry 2r5k coloured by chain, front view.
PDB entry 2r5k coloured by chain, side view.
PDB entry 2r5k coloured by chain, top view.
Source organism: human papillomavirus 11
Primary publication:
Crystal structures of four types of human papillomavirus L1 capsid proteins: understanding the specificity of neutralizing monoclonal antibodies.
Bishop B, Dasgupta J, Klein M, Garcea RL, Christensen ND, Zhao R, Chen XS
J Biol Chem 282 31803-11 (2007)
PMID: 17804402

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137320 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Major capsid protein L1 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 424 amino acids
Theoretical weight: 46.94 KDa
Source organism: human papillomavirus 11
Expression system: Escherichia coli
UniProt:
  • Canonical: P04012 (Residues: 20-399, 433-470; Coverage: 83%)
Gene name: L1
Sequence domains: L1 (late) protein
Structure domains: Major capsid L1 (late) superfamily, Papillomavirus

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: C2
Unit cell:
a: 115.71Å b: 159.97Å c: 158.44Å
α: 90° β: 101.83° γ: 90°
R-values:
R R work R free
0.289 0.289 0.317
Expression system: Escherichia coli

Quick links

Citations

17 review citations

Nuclear import by karyopherin-βs: recognition and inhibition.
Chook et al. (2011)
16 more

7 mentions without citation

Bioengineered Bovine Papillomavirus L1 Protein Virus-like Particle (VLP) Vaccines for Enhanced Induction of CD8 T Cell Responses through Cross-Priming.
Viscidi et al. (2023)
6 more