› 2r9y

X-ray diffraction
2.65Å resolution

Structure of antiplasmin

Released:
DOI: 10.2210/pdb2r9y/pdb
PDB entry 2r9y coloured by chain, front view.
PDB entry 2r9y coloured by chain, side view.
PDB entry 2r9y coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
X-ray crystal structure of the fibrinolysis inhibitor alpha2-antiplasmin.
Law RH, Sofian T, Kan WT, Horvath AJ, Hitchen CR, Langendorf CG, Buckle AM, Whisstock JC, Coughlin PB
Blood 111 2049-52 (2008)
PMID: 18063751

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178875 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-2-antiplasmin Chain: A
Molecule details ›
Chain: A
Length: 430 amino acids
Theoretical weight: 48.61 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q61247 (Residues: 71-491; Coverage: 91%)
Gene names: Pli, Serpinf2
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P65
Unit cell:
a: 115.679Å b: 115.679Å c: 100.533Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.186 0.184 0.218
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

10 review citations

New insights into the molecular mechanisms of the fibrinolytic system.
Rijken et al. (2009)
9 more

5 mentions without citation

α2-Antiplasmin as a Potential Therapeutic Target for Systemic Sclerosis.
Kanno et al. (2022)
4 more