› 2rc7

X-ray diffraction
1.58Å resolution

Crystal structure of the NR3A ligand binding core complex with glycine at 1.58 Angstrom resolution

Released:
DOI: 10.2210/pdb2rc7/pdb
PDB entry 2rc7 coloured by chain, front view.
PDB entry 2rc7 coloured by chain, side view.
PDB entry 2rc7 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors.
Yao Y, Harrison CB, Freddolino PL, Schulten K, Mayer ML
EMBO J 27 2158-70 (2008)
PMID: 18636091

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193094 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, NMDA 3A Chains: A, B
Molecule details ›
Chains: A, B
Length: 294 amino acids
Theoretical weight: 32.94 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9R1M7 (Residues: 511-915; Coverage: 26%)
Gene name: Grin3a
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

4 bound ligands:
Ligand BR 1 x BR
Ligand CL 7 x CL
Ligand GOL 4 x GOL
Ligand GLY 2 x GLY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 49.892Å b: 97.568Å c: 59.901Å
α: 90° β: 93.55° γ: 90°
R-values:
R R work R free
0.149 0.148 0.177
Expression system: Escherichia coli

Quick links

Citations

17 review citations

Molecular basis of NMDA receptor functional diversity.
Paoletti P. (2011)
16 more

11 mentions without citation

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
10 more