› 2reo

X-ray diffraction
2.65Å resolution

Crystal structure of human sulfotransferase 1C3 (Sult1C3) in complex with PAP

Released:
DOI: 10.2210/pdb2reo/pdb
PDB entry 2reo coloured by chain, front view.
PDB entry 2reo coloured by chain, side view.
PDB entry 2reo coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tempel W, Pan P, Dong A, Loppnau P, Arrowsmith CH, Edwards AM, Sundstrom M, Weigelt J, Bochkarev A, Plotnikov AN, Structural Genomics Consortium (SGC)

Function and Biology Details

Reactions catalysed: 
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate
3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179758 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sulfotransferase 1C3 Chain: A
Molecule details ›
Chain: A
Length: 305 amino acids
Theoretical weight: 35.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6IMI6 (Residues: 1-304; Coverage: 100%)
Gene name: SULT1C3
Sequence domains: Sulfotransferase domain
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

1 bound ligand:
Ligand A3P 1 x A3P
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P6122
Unit cell:
a: 93.23Å b: 93.23Å c: 146.43Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.228 0.226 0.279
Expression system: Escherichia coli

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