› 2rfa

X-ray diffraction
1.7Å resolution

Crystal structure of the mouse TRPV6 ankyrin repeat domain

Released:
DOI: 10.2210/pdb2rfa/pdb
PDB entry 2rfa coloured by chain, front view.
PDB entry 2rfa coloured by chain, side view.
PDB entry 2rfa coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural analyses of the ankyrin repeat domain of TRPV6 and related TRPV ion channels.
Phelps CB, Huang RJ, Lishko PV, Wang RR, Gaudet R
Biochemistry 47 2476-84 (2008)
PMID: 18232717

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187576 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 6 Chain: A
Molecule details ›
Chain: A
Length: 232 amino acids
Theoretical weight: 25.71 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q91WD2 (Residues: 84-305; Coverage: 29%)
Gene name: Trpv6
Sequence domains: Ankyrin repeats (3 copies)
Structure domains: Ankyrin repeat-containing domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 30.762Å b: 63.045Å c: 116.14Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.168 0.207
Expression system: Escherichia coli

Quick links

Citations

26 review citations

The vanilloid transient receptor potential channel TRPV4: from structure to disease.
Everaerts et al. (2010)
25 more

7 mentions without citation

X-ray crystallography of TRP channels.
Singh et al. (2018)
6 more