2riw

X-ray diffraction
2.04Å resolution

The Reactive loop cleaved human Thyroxine Binding Globulin complexed with thyroxine

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
monomeric
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-138703 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Thyroxine-binding globulin Chain: A
Molecule details ›
Chain: A
Length: 338 amino acids
Theoretical weight: 37.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05543 (Residues: 39-371; Coverage: 84%)
Gene names: SERPINA7, TBG
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:
Thyroxine-binding globulin Chain: B
Molecule details ›
Chain: B
Length: 40 amino acids
Theoretical weight: 4.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05543 (Residues: 377-415; Coverage: 10%)
Gene names: SERPINA7, TBG

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.1
Spacegroup: P21212
Unit cell:
a: 173.594Å b: 42.164Å c: 55.98Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.196 0.244
Expression system: Escherichia coli