› 2rkx

X-ray diffraction
2.25Å resolution

The 3D structure of chain D, cyclase subunit of imidazoleglycerol_evolvedcerolphosphate synthase

Released:
DOI: 10.2210/pdb2rkx/pdb
PDB entry 2rkx coloured by chain, front view.
PDB entry 2rkx coloured by chain, side view.
PDB entry 2rkx coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Kemp elimination catalysts by computational enzyme design.
Röthlisberger D, Khersonsky O, Wollacott AM, Jiang L, DeChancie J, Betker J, Gallaher JL, Althoff EA, Zanghellini A, Dym O, Albeck S, Houk KN, Tawfik DS, Baker D
Nature 453 190-5 (2008)
PMID: 18354394

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-163228 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclase subunit of imidazoleglycerol_evolvedcerolphosphate synthase Chain: A
Molecule details ›
Chain: A
Length: 255 amino acids
Theoretical weight: 28.05 KDa
Source organism: Synthetic construct
Expression system: Not provided
Structure domains: Aldolase class I

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P6122
Unit cell:
a: 96.38Å b: 96.38Å c: 153.988Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.207 0.206 0.235
Expression system: Not provided

Quick links

Citations

186 review citations

The role of dynamic conformational ensembles in biomolecular recognition.
Boehr et al. (2009)
185 more

11 mentions without citation

Optimizing non-natural protein function with directed evolution.
Brustad et al. (2011)
10 more