› 2rm4

Solution NMR

Solution Structure of the LSM Domain of Dm EDC3 (Enhancer of DECAPPING 3)

Released:
DOI: 10.2210/pdb2rm4/pdb
PDB entry 2rm4 coloured by chain, ensemble of 22 models, front view.
PDB entry 2rm4 coloured by chain, ensemble of 22 models, side view.
PDB entry 2rm4 coloured by chain, ensemble of 22 models, top view.
Source organism: Drosophila melanogaster
Primary publication:
A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting.
Tritschler F, Eulalio A, Truffault V, Hartmann MD, Helms S, Schmidt S, Coles M, Izaurralde E, Weichenrieder O
Mol Cell Biol 27 8600-11 (2007)
PMID: 17923697

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194317 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Enhancer of mRNA-decapping protein 3 Chain: A
Molecule details ›
Chain: A
Length: 103 amino acids
Theoretical weight: 11.1 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9VVI2 (Residues: 1-101; Coverage: 15%)
Gene names: CG6311, Edc3
Sequence domains: Scd6-like Sm domain
Structure domains: SH3 type barrels.

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

18 review citations

The control of mRNA decapping and P-body formation.
Franks et al. (2008)
17 more

2 mentions without citation

The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex.
Fromm et al. (2012)
1 more