› 2rpn

Solution NMR

A crucial role for high intrinsic specificity in the function of yeast SH3 domains

Released:
DOI: 10.2210/pdb2rpn/pdb
PDB entry 2rpn coloured by chain, ensemble of 20 models, front view.
PDB entry 2rpn coloured by chain, ensemble of 20 models, side view.
PDB entry 2rpn coloured by chain, ensemble of 20 models, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Structural, functional, and bioinformatic studies demonstrate the crucial role of an extended peptide binding site for the SH3 domain of yeast Abp1p.
Stollar EJ, Garcia B, Chong PA, Rath A, Lin H, Forman-Kay JD, Davidson AR
J Biol Chem 284 26918-27 (2009)
PMID: 19590096

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147522 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Actin-binding protein Chain: A
Molecule details ›
Chain: A
Length: 59 amino acids
Theoretical weight: 6.73 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: P15891 (Residues: 535-592; Coverage: 10%)
Gene names: ABP1, YCR088W, YCR88W
Sequence domains: SH3 domain
Structure domains: SH3 Domains
Actin-regulating kinase 1 Chain: B
Molecule details ›
Chain: B
Length: 18 amino acids
Theoretical weight: 1.99 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: P53974 (Residues: 605-621; Coverage: 3%)
Gene names: ARK1, N2823, YNL020C

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

1 review citation

The mammalian actin-binding protein 1 (mAbp1): a novel molecular player in leukocyte biology.
Schymeinsky et al. (2011)
15 other articles

8 mentions without citation

Structural, functional, and bioinformatic studies demonstrate the crucial role of an extended peptide binding site for the SH3 domain of yeast Abp1p.
Stollar et al. (2009)
7 more