› 2rsg

Solution NMR

Solution structure of the CERT PH domain

Released:
DOI: 10.2210/pdb2rsg/pdb
PDB entry 2rsg coloured by chain, ensemble of 20 models, front view.
PDB entry 2rsg coloured by chain, ensemble of 20 models, side view.
PDB entry 2rsg coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the Golgi association by the pleckstrin homology domain of the ceramide trafficking protein (CERT).
Sugiki T, Takeuchi K, Yamaji T, Takano T, Tokunaga Y, Kumagai K, Hanada K, Takahashi H, Shimada I
J Biol Chem 287 33706-18 (2012)
PMID: 22869376

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195280 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ceramide transfer protein Chain: A
Molecule details ›
Chain: A
Length: 94 amino acids
Theoretical weight: 11.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y5P4 (Residues: 24-117; Coverage: 15%)
Gene names: CERT, CERT1, COL4A3BP, STARD11
Sequence domains: PH domain
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 83%
Refinement method: distance geometry
Expression system: Escherichia coli

Quick links

Citations

15 review citations

Sphingolipid metabolism and interorganellar transport: localization of sphingolipid enzymes and lipid transfer proteins.
Yamaji et al. (2015)
14 more

7 mentions without citation

ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane.
Ghai et al. (2017)
6 more