› 2rsk

Solution NMR

RNA aptamer against prion protein in complex with the partial binding peptide

Released:
DOI: 10.2210/pdb2rsk/pdb
PDB entry 2rsk coloured by chain, ensemble of 10 models, front view.
PDB entry 2rsk coloured by chain, ensemble of 10 models, side view.
PDB entry 2rsk coloured by chain, ensemble of 10 models, top view.
Source organism: Bos taurus
Primary publication:
Anti-prion activity of an RNA aptamer and its structural basis.
Mashima T, Nishikawa F, Kamatari YO, Fujiwara H, Saimura M, Nagata T, Kodaki T, Nishikawa S, Kuwata K, Katahira M
Nucleic Acids Res 41 1355-62 (2013)
PMID: 23180780

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145259 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Major prion protein Chains: C, D
Molecule details ›
Chains: C, D
Length: 12 amino acids
Theoretical weight: 1.39 KDa
Source organism: Bos taurus
Expression system: Not provided
UniProt:
  • Canonical: P10279 (Residues: 108-119; Coverage: 5%)
Gene names: PRNP, PRP
RNA (5'-R(*GP*GP*AP*GP*GP*AP*GP*GP*AP*GP*GP*A)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 12 nucleotides
Theoretical weight: 4.03 KDa
Source organism: Bos taurus
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 19%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

13 review citations

G-quadruplex-based aptamers against protein targets in therapy and diagnostics.
Platella et al. (2017)
12 more

5 mentions without citation

The emerging structural complexity of G-quadruplex RNAs.
Banco et al. (2021)
4 more