› 2ru7

Solution NMR

Refined structure of RNA aptamer in complex with the partial binding peptide of prion protein

Released:
DOI: 10.2210/pdb2ru7/pdb
PDB entry 2ru7 coloured by chain, ensemble of 5 models, front view.
PDB entry 2ru7 coloured by chain, ensemble of 5 models, side view.
PDB entry 2ru7 coloured by chain, ensemble of 5 models, top view.
Source organism: Bos taurus
Primary publication:
Binding of an RNA aptamer and a partial peptide of a prion protein: crucial importance of water entropy in molecular recognition.
Hayashi T, Oshima H, Mashima T, Nagata T, Katahira M, Kinoshita M
Nucleic Acids Res 42 6861-75 (2014)
PMID: 24803670

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145260 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Major prion protein Chains: C, D
Molecule details ›
Chains: C, D
Length: 12 amino acids
Theoretical weight: 1.39 KDa
Source organism: Bos taurus
Expression system: Not provided
UniProt:
  • Canonical: P10279 (Residues: 108-119; Coverage: 5%)
Gene names: PRNP, PRP
RNA_(5'-R(*GP*GP*AP*GP*GP*AP*GP*GP*AP*GP*GP*A)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 12 nucleotides
Theoretical weight: 4.03 KDa
Source organism: Bos taurus
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 20%
Refinement method: energy minimization, simulated annealing
Expression system: Not provided

Quick links

Citations

8 review citations

Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications.
Guan et al. (2020)
7 more

6 mentions without citation

On Characterizing the Interactions between Proteins and Guanine Quadruplex Structures of Nucleic Acids.
McRae et al. (2017)
5 more