› 2rug

Solution NMR

Refined solution structure of the first RNA recognition motif domain in CPEB3

Released:
DOI: 10.2210/pdb2rug/pdb
PDB entry 2rug coloured by chain, ensemble of 20 models, front view.
PDB entry 2rug coloured by chain, ensemble of 20 models, side view.
PDB entry 2rug coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Novel RNA recognition motif domain in the cytoplasmic polyadenylation element binding protein 3.
Tsuda K, Kuwasako K, Nagata T, Takahashi M, Kigawa T, Kobayashi N, Güntert P, Shirouzu M, Yokoyama S, Muto Y
Proteins 82 2879-86 (2014)
PMID: 25066254

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185504 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytoplasmic polyadenylation element-binding protein 3 Chain: A
Molecule details ›
Chain: A
Length: 114 amino acids
Theoretical weight: 12.43 KDa
Source organism: Homo sapiens
Expression system: Cell-free synthesis
UniProt:
  • Canonical: Q8NE35 (Residues: 440-540; Coverage: 15%)
Gene names: CPEB3, KIAA0940
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 94%
Refinement method: simulated annealing
Expression system: Cell-free synthesis

Quick links

Citations

2 citation in other articles

Oligomeric transition and dynamics of RNA binding by the HuR RRM1 domain in solution.
Lixa et al. (2018)
1 more

1 mention without citation

Role of CPEB3 protein in learning and memory: new insights from synaptic plasticity.
Qu et al. (2020)