Function and Biology Details
Reaction catalysed:
Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Proteinase inhibitor I16, Streptomyces subtilisin-type inhibitor
- Peptidase S8, subtilisin-related
- Peptidase S8/S53 domain superfamily
- Proteinase inhibitor I16, Streptomyces subtilisin-type inhibitor, conserved site
- Subtilisin inhibitor
- Subtilisin inhibitor-like superfamily
- Peptidase S8, subtilisin, Ser-active site
- Peptidase S8, subtilisin, His-active site
3 more domains
Structure domains:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
Subtilisin BPN' and Subtilisin inhibitor (preferred)
PDBe Complex ID:
PDB-CPX-133537 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Subtilisin BPN'
Molecule details ›
Chain: E
Length: 275 amino acids
Theoretical weight: 27.55 KDa
Source organism: Bacillus amyloliquefaciens
Expression system: Not provided
UniProt:
Sequence domains: Subtilase family
Structure domains: Peptidase S8/S53 domain
Length: 275 amino acids
Theoretical weight: 27.55 KDa
Source organism: Bacillus amyloliquefaciens
Expression system: Not provided
UniProt:
- Canonical:
P00782 (Residues: 108-382; Coverage: 78%)
Sequence domains: Subtilase family
Structure domains: Peptidase S8/S53 domain
Subtilisin inhibitor
Molecule details ›
Chain: I
Length: 107 amino acids
Theoretical weight: 10.94 KDa
Source organism: Streptomyces albogriseolus
Expression system: Not provided
UniProt:
Sequence domains: Subtilisin inhibitor-like
Structure domains: Subtilisin inhibitor-like
Length: 107 amino acids
Theoretical weight: 10.94 KDa
Source organism: Streptomyces albogriseolus
Expression system: Not provided
UniProt:
- Canonical: P01006 (Residues: 38-144; Coverage: 95%)
Sequence domains: Subtilisin inhibitor-like
Structure domains: Subtilisin inhibitor-like
