› 2up1

X-ray diffraction
2.1Å resolution

STRUCTURE OF UP1-TELOMERIC DNA COMPLEX

Released:
DOI: 10.2210/pdb2up1/pdb
PDB entry 2up1 coloured by chain, front view.
PDB entry 2up1 coloured by chain, side view.
PDB entry 2up1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the two-RRM domain of hnRNP A1 (UP1) complexed with single-stranded telomeric DNA.
Ding J, Hayashi MK, Zhang Y, Manche L, Krainer AR, Xu RM
Genes Dev 13 1102-15 (1999)
PMID: 10323862

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115850 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed Chain: A
Molecule details ›
Chain: A
Length: 183 amino acids
Theoretical weight: 20.88 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P09651 (Residues: 8-190; Coverage: 49%)
Gene names: HNRNPA1, HNRPA1
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits
DNA (5'-D(P*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*G)-3') Chain: B
Molecule details ›
Chain: B
Length: 11 nucleotides
Theoretical weight: 3.47 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P43212
Unit cell:
a: 51.2Å b: 51.2Å c: 171.09Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.195 0.249
Expression system: Not provided

Quick links

Citations

36 review citations

Mechanisms of alternative pre-messenger RNA splicing.
Black DL. (2003)
35 more

18 mentions without citation

Sequence-specific binding of single-stranded RNA: is there a code for recognition?
Auweter et al. (2006)
17 more