› 2uux

X-ray diffraction
1.4Å resolution

Structure of the tryptase inhibitor TdPI from a tick

Released:
DOI: 10.2210/pdb2uux/pdb
PDB entry 2uux coloured by chain, front view.
PDB entry 2uux coloured by chain, side view.
PDB entry 2uux coloured by chain, top view.
Source organism: Rhipicephalus appendiculatus
Primary publication:
A tick protein with a modified Kunitz fold inhibits human tryptase.
Paesen GC, Siebold C, Harlos K, Peacey MF, Nuttall PA, Stuart DI
J Mol Biol 368 1172-86 (2007)
PMID: 17391695

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172815 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tryptase inhibitor Chain: A
Molecule details ›
Chain: A
Length: 55 amino acids
Theoretical weight: 6.05 KDa
Source organism: Rhipicephalus appendiculatus
UniProt:
  • Canonical: Q1EG59 (Residues: 44-96; Coverage: 55%)
Structure domains: Pancreatic trypsin inhibitor Kunitz domain

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P21212
Unit cell:
a: 53.676Å b: 28.594Å c: 30.11Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.171 0.168 0.224

Quick links

Citations

18 review citations

The role of saliva in tick feeding.
Francischetti et al. (2009)
17 more

8 mentions without citation

Serine Protease Inhibitors in Ticks: An Overview of Their Role in Tick Biology and Tick-Borne Pathogen Transmission.
Blisnick et al. (2017)
7 more