› 2uxs

X-ray diffraction
2.7Å resolution

2.7A crystal structure of inorganic pyrophosphatase (Rv3628) from Mycobacterium tuberculosis at pH 7.5

Released:
DOI: 10.2210/pdb2uxs/pdb
PDB entry 2uxs coloured by chain, front view.
PDB entry 2uxs coloured by chain, side view.
PDB entry 2uxs coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Entry authors: Cole RE, Cianci M, Hall JF, Matsuda T, Kigawa T, Yokoyama S, Hasnain SS, Tabernero L

Function and Biology Details

Reaction catalysed: 
Diphosphate + H(2)O = 2 phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161596 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inorganic pyrophosphatase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 169 amino acids
Theoretical weight: 18.84 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WI55 (Residues: 1-162; Coverage: 100%)
Gene names: MTCY15C10.24, Rv3628, ppa
Sequence domains: Inorganic pyrophosphatase
Structure domains: Inorganic pyrophosphatase

Ligands and Environments

1 bound ligand:
Ligand PO4 3 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX10.1
Spacegroup: P3221
Unit cell:
a: 102.022Å b: 102.022Å c: 80.812Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.234 0.232 0.274
Expression system: Escherichia coli

Quick links