› 2uz6

X-ray diffraction
2.4Å resolution

AChBP-targeted a-conotoxin correlates distinct binding orientations with nAChR subtype selectivity.

Released:
DOI: 10.2210/pdb2uz6/pdb
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PDB entry 2uz6 coloured by chain, front view.
PDB entry 2uz6 coloured by chain, side view.
PDB entry 2uz6 coloured by chain, top view.
Source organisms:
Primary publication:
AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity.
Dutertre S, Ulens C, Büttner R, Fish A, van Elk R, Kendel Y, Hopping G, Alewood PF, Schroeder C, Nicke A, Smit AB, Sixma TK, Lewis RJ
OpenAccess logo EMBO J 26 3858-67 (2007)
PMID: 17660751

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-163256 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Neurotransmitter-gated ion-channel ligand-binding domain-containing protein Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 217 amino acids
Theoretical weight: 24.69 KDa
Source organism: Aplysia californica
UniProt:
  • Canonical: Q8WSF8 (Residues: 20-236; Coverage: 100%)
Sequence domains: Neurotransmitter-gated ion-channel ligand binding domain
Structure domains: Neurotransmitter-gated ion-channel ligand-binding domain
ALPHA-CONOTOXIN TXIA(A10L) Chains: K, L, M, N, O, P, Q, R, S, T
Molecule details ›
Chains: K, L, M, N, O, P, Q, R, S, T
Length: 17 amino acids
Theoretical weight: 1.7 KDa
Source organism: Conus textile
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand NAG 2 x NAG
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P1
Unit cell:
a: 72.54Å b: 85.754Å c: 121.667Å
α: 90.14° β: 80.01° γ: 70.64°
R-values:
R R work R free
0.237 0.236 0.252
Expression system: Not provided

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Citations

21 review citations

Conus venom peptide pharmacology.
Lewis et al. (2012)
20 more

25 mentions without citation

Discovery, synthesis, and structure-activity relationships of conotoxins.
Akondi et al. (2014)
24 more

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