› 2v26

X-ray diffraction
1.75Å resolution

Myosin VI (MD) pre-powerstroke state (Mg.ADP.VO4)

Released:
DOI: 10.2210/pdb2v26/pdb
PDB entry 2v26 coloured by chain, front view.
PDB entry 2v26 coloured by chain, side view.
PDB entry 2v26 coloured by chain, top view.
Source organism: Sus scrofa
Primary publication:
The structural basis for the large powerstroke of myosin VI.
Ménétrey J, Llinas P, Mukherjea M, Sweeney HL, Houdusse A
Cell 131 300-8 (2007)
PMID: 17956731

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173344 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Unconventional myosin-VI Chain: A
Molecule details ›
Chain: A
Length: 784 amino acids
Theoretical weight: 89.43 KDa
Source organism: Sus scrofa
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q29122 (Residues: 5-789; Coverage: 63%)
Gene name: MYO6
Sequence domains: Myosin head (motor domain)
Structure domains:

Ligands and Environments

5 bound ligands:
Ligand ADP 1 x ADP
Ligand VO4 1 x VO4
Ligand EDO 7 x EDO
Ligand SO4 2 x SO4
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P212121
Unit cell:
a: 93.512Å b: 93.845Å c: 100.976Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.202 0.227
Expression system: Spodoptera frugiperda

Quick links

Citations

8 review citations

Structural and functional insights into the Myosin motor mechanism.
Sweeney et al. (2010)
7 more

19 mentions without citation

Myosin VI: an innovative motor that challenged the swinging lever arm hypothesis.
Spudich et al. (2010)
18 more