› 2v3u

X-ray diffraction
1.74Å resolution

Structure of the ligand-binding core of the ionotropic glutamate receptor-like GluRdelta2 in complex with D-serine

Released:
DOI: 10.2210/pdb2v3u/pdb
PDB entry 2v3u coloured by chain, front view.
PDB entry 2v3u coloured by chain, side view.
PDB entry 2v3u coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Ionotropic glutamate-like receptor delta2 binds D-serine and glycine.
Naur P, Hansen KB, Kristensen AS, Dravid SM, Pickering DS, Olsen L, Vestergaard B, Egebjerg J, Gajhede M, Traynelis SF, Kastrup JS
Proc Natl Acad Sci U S A 104 14116-21 (2007)
PMID: 17715062

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179000 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, delta-2 Chain: A
Molecule details ›
Chain: A
Length: 265 amino acids
Theoretical weight: 29.94 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q63226 (Residues: 440-813; Coverage: 27%)
Gene name: Grid2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

4 bound ligands:
Ligand DSN 1 x DSN
Ligand NA 1 x NA
Ligand CL 1 x CL
Ligand SCN 2 x SCN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P1
Unit cell:
a: 36.801Å b: 40.307Å c: 44.393Å
α: 66.88° β: 79.31° γ: 86.46°
R-values:
R R work R free
0.2 0.197 0.25
Expression system: Escherichia coli

Quick links

Citations

25 review citations

Ionotropic GABA and Glutamate Receptor Mutations and Human Neurologic Diseases.
Yuan et al. (2015)
24 more

8 mentions without citation

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
7 more