› 2v41

X-ray diffraction
2.4Å resolution

Crystal Structure of the C45S mutant of the Peroxiredoxin 6 of Arenicola Marina. Orthorhombic form

Released:
DOI: 10.2210/pdb2v41/pdb
PDB entry 2v41 coloured by chain, front view.
PDB entry 2v41 coloured by chain, side view.
PDB entry 2v41 coloured by chain, top view.
Source organism: Arenicola marina
Primary publication:
The crystal structure of the C45S mutant of annelid Arenicola marina peroxiredoxin 6 supports its assignment to the mechanistically typical 2-Cys subfamily without any formation of toroid-shaped decamers.
Smeets A, Loumaye E, Clippe A, Rees JF, Knoops B, Declercq JP
Protein Sci 17 700-10 (2008)
PMID: 18359859

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172774 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thioredoxin domain-containing protein Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 233 amino acids
Theoretical weight: 25.81 KDa
Source organism: Arenicola marina
Expression system: Escherichia coli
UniProt:
  • Canonical: Q1AN22 (Residues: 1-220; Coverage: 100%)
Gene name: Prdx6
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand BEZ 8 x BEZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM30A
Spacegroup: P212121
Unit cell:
a: 77.11Å b: 111.156Å c: 229.8Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.177 0.239
Expression system: Escherichia coli

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Citations

1 review citation

The oligomeric conformation of peroxiredoxins links redox state to function.
Barranco-Medina et al. (2009)
10 other articles

4 mentions without citation

Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins.
Hall et al. (2011)
3 more