› 2v5m

X-ray diffraction
1.95Å resolution

Structural basis for Dscam isoform specificity

Released:
DOI: 10.2210/pdb2v5m/pdb
PDB entry 2v5m coloured by chain, front view.
PDB entry 2v5m coloured by chain, side view.
PDB entry 2v5m coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Structural basis of Dscam isoform specificity.
Meijers R, Puettmann-Holgado R, Skiniotis G, Liu JH, Walz T, Wang JH, Schmucker D
Nature 449 487-91 (2007)
PMID: 17721508

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192416 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Cell adhesion molecule Dscam1 Chain: A
Molecule details ›
Chain: A
Length: 388 amino acids
Theoretical weight: 42.88 KDa
Source organism: Drosophila melanogaster
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q0E9H9 (Residues: 36-423; Coverage: 20%)
Gene names: CG17800, Dscam, Dscam1, p270
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P4222
Unit cell:
a: 99.172Å b: 99.172Å c: 163.991Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.171 0.169 0.205
Expression system: Spodoptera frugiperda

Quick links

Citations

34 review citations

Immune proteins in brain development and synaptic plasticity.
Boulanger LM. (2009)
33 more

5 mentions without citation

Designing specific protein-protein interactions using computation, experimental library screening, or integrated methods.
Chen et al. (2012)
4 more