› 2v5r

X-ray diffraction
3Å resolution

Structural basis for Dscam isoform specificity

Released:
DOI: 10.2210/pdb2v5r/pdb
PDB entry 2v5r coloured by chain, front view.
PDB entry 2v5r coloured by chain, side view.
PDB entry 2v5r coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Structural basis of Dscam isoform specificity.
Meijers R, Puettmann-Holgado R, Skiniotis G, Liu JH, Walz T, Wang JH, Schmucker D
Nature 449 487-91 (2007)
PMID: 17721508

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192416 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cell adhesion molecule Dscam1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 391 amino acids
Theoretical weight: 43.48 KDa
Source organism: Drosophila melanogaster
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q0E9H9 (Residues: 36-186, 187-258, 259-423; Coverage: 20%)
Gene names: CG17800, Dscam, Dscam1, p270
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand NAG 8 x NAG
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2
Unit cell:
a: 277.781Å b: 70.548Å c: 72.771Å
α: 90° β: 105.13° γ: 90°
R-values:
R R work R free
0.271 0.271 0.303
Expression system: Spodoptera frugiperda

Quick links

Citations

33 review citations

Immune proteins in brain development and synaptic plasticity.
Boulanger LM. (2009)
32 more

5 mentions without citation

Protein-protein interaction networks: how can a hub protein bind so many different partners?
Tsai et al. (2009)
4 more