› 2v6o

X-ray diffraction
2.2Å resolution

Structure of Schistosoma mansoni Thioredoxin-Glutathione Reductase (SmTGR)

Released:
DOI: 10.2210/pdb2v6o/pdb
PDB entry 2v6o coloured by chain, front view.
PDB entry 2v6o coloured by chain, side view.
PDB entry 2v6o coloured by chain, top view.
Source organism: Schistosoma mansoni
Primary publication:
Glutathione reductase and thioredoxin reductase at the crossroad: the structure of Schistosoma mansoni thioredoxin glutathione reductase.
Angelucci F, Miele AE, Boumis G, Dimastrogiovanni D, Brunori M, Bellelli A
Proteins 72 936-45 (2008)
PMID: 18300227

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188301 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
thioredoxin-disulfide reductase Chain: A
Molecule details ›
Chain: A
Length: 596 amino acids
Theoretical weight: 64.9 KDa
Source organism: Schistosoma mansoni
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q962Y6 (Residues: 1-596; Coverage: 100%)
Gene name: TGR
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand FAD 1 x FAD
Ligand PG4 4 x PG4
Ligand NO3 1 x NO3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: C2
Unit cell:
a: 142.324Å b: 102.533Å c: 59.027Å
α: 90° β: 112.63° γ: 90°
R-values:
R R work R free
0.191 0.188 0.252
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Thioredoxin reductase and its inhibitors.
Saccoccia et al. (2014)
5 more

11 mentions without citation

Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects.
Angelucci et al. (2009)
10 more