› 2v90

X-ray diffraction
2Å resolution

Crystal structure of the 3rd PDZ domain of intestine- and kidney- enriched PDZ domain IKEPP (PDZD3)

Released:
DOI: 10.2210/pdb2v90/pdb
PDB entry 2v90 coloured by chain, front view.
PDB entry 2v90 coloured by chain, side view.
PDB entry 2v90 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Uppenberg J, Gileadi C, Phillips C, Elkins J, Bunkoczi G, Cooper C, Pike ACW, Salah E, Ugochukwu E, Arrowsmith CH, Edwards A, Sundstrom M, Weigelt J, Doyle DA

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183187 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Na(+)/H(+) exchange regulatory cofactor NHE-RF4 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 96 amino acids
Theoretical weight: 10.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q86UT5 (Residues: 326-419; Coverage: 17%)
Gene names: DLNB27, IKEPP, NHERF4, PDZD3, PDZK2
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

1 bound ligand:
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 48.15Å b: 97.95Å c: 59.5Å
α: 90° β: 99.59° γ: 90°
R-values:
R R work R free
0.196 0.193 0.256
Expression system: Escherichia coli BL21(DE3)

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