› 2v95

X-ray diffraction
1.93Å resolution

Structure of Corticosteroid-Binding Globulin in complex with Cortisol

Released:
DOI: 10.2210/pdb2v95/pdb
PDB entry 2v95 coloured by chain, front view.
PDB entry 2v95 coloured by chain, side view.
PDB entry 2v95 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Corticosteroid-binding globulin, a structural basis for steroid transport and proteinase-triggered release.
Klieber MA, Underhill C, Hammond GL, Muller YA
J Biol Chem 282 29594-603 (2007)
PMID: 17644521

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151925 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Corticosteroid-binding globulin Chain: A
Molecule details ›
Chain: A
Length: 371 amino acids
Theoretical weight: 41.89 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P31211 (Residues: 27-396; Coverage: 99%)
Gene names: Cbg, Serpina6
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand HCY 1 x HCY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: C2
Unit cell:
a: 122.11Å b: 54.25Å c: 61.04Å
α: 90° β: 97.16° γ: 90°
R-values:
R R work R free
0.214 0.21 0.264
Expression system: Escherichia coli BL21(DE3)

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Citations

15 review citations

Unraveling the time domains of corticosteroid hormone influences on brain activity: rapid, slow, and chronic modes.
Joëls et al. (2012)
14 more

10 mentions without citation

Avian corticosteroid-binding globulin: biological function and regulatory mechanisms in physiological stress responses.
Lin et al. (2021)
9 more