› 2vaa

X-ray diffraction
2.3Å resolution

MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND VESICULAR STOMATITIS VIRUS NUCLEOPROTEIN

Released:
DOI: 10.2210/pdb2vaa/pdb
PDB entry 2vaa coloured by chain, front view.
PDB entry 2vaa coloured by chain, side view.
PDB entry 2vaa coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb.
Fremont DH, Matsumura M, Stura EA, Peterson PA, Wilson IA
Science 257 919-27 (1992)
PMID: 1323877

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-135046 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
H-2 class I histocompatibility antigen, K-B alpha chain Chain: A
Molecule details ›
Chain: A
Length: 274 amino acids
Theoretical weight: 31.65 KDa
Source organism: Mus musculus
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P01901 (Residues: 22-295; Coverage: 79%)
Gene names: H2-K, H2-K1
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 99 amino acids
Theoretical weight: 11.7 KDa
Source organism: Mus musculus
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P01887 (Residues: 21-119; Coverage: 100%)
Gene name: B2m
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Nucleoprotein Chain: P
Molecule details ›
Chain: P
Length: 8 amino acids
Theoretical weight: 956 Da
Source organism: Vesicular stomatitis virus
Expression system: Not provided
UniProt:
  • Canonical: P11212 (Residues: 52-59; Coverage: 2%)
Gene name: N

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21212
Unit cell:
a: 138.1Å b: 88.9Å c: 45.7Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.171 0.171 not available
Expression systems:
  • Drosophila melanogaster
  • Not provided

Quick links

Citations

112 review citations

MHC ligands and peptide motifs: first listing.
Rammensee et al. (1995)
111 more

18 mentions without citation

50 Years of structural immunology.
Wilson et al. (2021)
17 more