› 2vac

X-ray diffraction
1.7Å resolution

Structure of N-terminal Actin Depolymerizing Factor homology (ADF-H) domain of human twinfilin-2

Released:
DOI: 10.2210/pdb2vac/pdb
PDB entry 2vac coloured by chain, front view.
PDB entry 2vac coloured by chain, side view.
PDB entry 2vac coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Elkins JM, Pike ACW, King O, Salah E, Savitsky P, von Delft F, Weigelt J, Edwards A, Arrowsmith CH, Sundstrom M, Knapp S

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179753 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Twinfilin-2 Chain: A
Molecule details ›
Chain: A
Length: 134 amino acids
Theoretical weight: 15.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q6IBS0 (Residues: 6-137; Coverage: 38%)
Gene names: MSTP011, PTK9L, TWF2
Sequence domains: Cofilin/tropomyosin-type actin-binding protein
Structure domains: Severin

Ligands and Environments

2 bound ligands:
Ligand ZN 3 x ZN
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E
Spacegroup: P212121
Unit cell:
a: 35.817Å b: 48.56Å c: 70.127Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.17 0.214
Expression system: Escherichia coli BL21(DE3)

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