› 2vh4

X-ray diffraction
2.45Å resolution

Structure of a loop C-sheet serpin polymer

Released:
DOI: 10.2210/pdb2vh4/pdb
PDB entry 2vh4 coloured by chain, front view.
PDB entry 2vh4 coloured by chain, side view.
PDB entry 2vh4 coloured by chain, top view.
Source organism: Caldanaerobacter subterraneus subsp. tengcongensis MB4
Primary publication:
A structural basis for loop C-sheet polymerization in serpins.
Zhang Q, Law RH, Bottomley SP, Whisstock JC, Buckle AM
J Mol Biol 376 1348-59 (2008)
PMID: 18234218

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185939 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serpin domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 381 amino acids
Theoretical weight: 43.11 KDa
Source organism: Caldanaerobacter subterraneus subsp. tengcongensis MB4
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8R9P5 (Residues: 43-423; Coverage: 90%)
Gene name: TTE1560
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P21
Unit cell:
a: 42.895Å b: 68.669Å c: 137.651Å
α: 90° β: 93.45° γ: 90°
R-values:
R R work R free
0.196 0.192 0.262
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Conformational pathology of the serpins: themes, variations, and therapeutic strategies.
Gooptu et al. (2009)
2 more