› 2vim

X-ray diffraction
1.38Å resolution

X-ray structure of Fasciola hepatica thioredoxin

Released:
DOI: 10.2210/pdb2vim/pdb
PDB entry 2vim coloured by chain, front view.
PDB entry 2vim coloured by chain, side view.
PDB entry 2vim coloured by chain, top view.
Source organism: Fasciola hepatica
Primary publication:
The Fasciola hepatica thioredoxin: High resolution structure reveals two oxidation states.
Line K, Isupov MN, Garcia-Rodriguez E, Maggioli G, Parra F, Littlechild JA
Mol Biochem Parasitol 161 44-8 (2008)
PMID: 18620002

Function and Biology Details

Reaction catalysed: 
Adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin
Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193596 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thioredoxin Chain: A
Molecule details ›
Chain: A
Length: 104 amino acids
Theoretical weight: 11.7 KDa
Source organism: Fasciola hepatica
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9U1G7 (Residues: 1-104; Coverage: 100%)
Gene name: trx
Sequence domains: Thioredoxin
Structure domains: Glutaredoxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup: P21
Unit cell:
a: 32.666Å b: 34.586Å c: 40.381Å
α: 90° β: 106.63° γ: 90°
R-values:
R R work R free
0.192 0.189 0.248
Expression system: Escherichia coli BL21

Quick links

Citations

3 review citations

Thioredoxin glutathione reductase-dependent redox networks in platyhelminth parasites.
Williams et al. (2013)
2 more

11 mentions without citation

The intermediate filament protein peripherin is the specific interaction partner of mouse BPAG1-n (dystonin) in neurons.
Leung et al. (1999)
10 more