Function and Biology Details
Reactions catalysed:
Phenylpyruvate = phenylacetaldehyde + CO(2)
(3S)-3-methyl-2-oxopentanoate = 2-methylbutanal + CO(2)
3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Thiamin diphosphate-binding fold
- Pyruvate decarboxylase/indolepyruvate decarboxylase-like
- TPP-binding enzyme, conserved site
- Thiamine pyrophosphate enzyme, TPP-binding
- Pyruvate decarboxylase/indolepyruvate decarboxylase-like, PP-binding domain
- Thiamine pyrophosphate enzyme, central domain
- DHS-like NAD/FAD-binding domain superfamily
- Pyruvate decarboxylase/indolepyruvate decarboxylase-like, pyrimidine-binding domain
1 more domain
Structure analysis Details
Assembly composition:
homo dimer (preferred)
Assembly name:
Pyruvate decarboxylase isozyme 1 (preferred)
PDBe Complex ID:
PDB-CPX-138889 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pyruvate decarboxylase isozyme 1
Molecule details ›
Chains: A, B, C, D
Length: 563 amino acids
Theoretical weight: 61.59 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 563 amino acids
Theoretical weight: 61.59 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
- Canonical:
P06169 (Residues: 1-563; Coverage: 100%)
Sequence domains:
- Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
- Thiamine pyrophosphate enzyme, central domain
- Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
