› 2vl0

X-ray diffraction
3.3Å resolution

X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC)

Released:
DOI: 10.2210/pdb2vl0/pdb
PDB entry 2vl0 coloured by chain, front view.
PDB entry 2vl0 coloured by chain, side view.
PDB entry 2vl0 coloured by chain, top view.
Source organism: Dickeya chrysanthemi
Primary publication:
X-ray structure of a prokaryotic pentameric ligand-gated ion channel.
Hilf RJ, Dutzler R
Nature 452 375-9 (2008)
PMID: 18322461

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143154 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cys-loop ligand-gated ion channel Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 321 amino acids
Theoretical weight: 36.82 KDa
Source organism: Dickeya chrysanthemi
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P0C7B7 (Residues: 1-321; Coverage: 100%)
Sequence domains: Neurotransmitter-gated ion-channel ligand binding domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 105.502Å b: 266.147Å c: 110.851Å
α: 90° β: 109.52° γ: 90°
R-values:
R R work R free
0.263 0.263 0.274
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

116 review citations

GABA A receptors: subtypes provide diversity of function and pharmacology.
Olsen et al. (2009)
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57 mentions without citation

Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes.
Lundbaek et al. (2010)
56 more