› 2vm5

X-ray diffraction
1.8Å resolution

HUMAN BIR2 DOMAIN OF BACULOVIRAL INHIBITOR OF APOPTOSIS REPEAT- CONTAINING 1 (BIRC1)

Released:
DOI: 10.2210/pdb2vm5/pdb
PDB entry 2vm5 coloured by chain, front view.
PDB entry 2vm5 coloured by chain, side view.
PDB entry 2vm5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of BIR domains from human NAIP and cIAP2.
Herman MD, Moche M, Flodin S, Welin M, Trésaugues L, Johansson I, Nilsson M, Nordlund P, Nyman T
Acta Crystallogr Sect F Struct Biol Cryst Commun 65 1091-6 (2009)
PMID: 19923725

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171520 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Baculoviral IAP repeat-containing protein 1 Chain: A
Molecule details ›
Chain: A
Length: 106 amino acids
Theoretical weight: 12.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13075 (Residues: 139-244; Coverage: 8%)
Gene names: BIRC1, NAIP
Sequence domains: Inhibitor of Apoptosis domain
Structure domains: Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A

Ligands and Environments

2 bound ligands:
Ligand ZN 1 x ZN
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P212121
Unit cell:
a: 36.5Å b: 43.1Å c: 57Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.178 0.22
Expression system: Escherichia coli BL21(DE3)

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Citations

1 review citation

Zinc-rich inhibitor of apoptosis proteins (IAPs) as regulatory factors in the epithelium of normal and inflamed airways.
Roscioli et al. (2013)
9 other articles

5 mentions without citation

Emerging significance of NLRs in inflammatory bowel disease.
Davis et al. (2014)
4 more