› 2vn8

X-ray diffraction
2.1Å resolution

Crystal structure of human Reticulon 4 interacting protein 1 in complex with NADPH

Released:
DOI: 10.2210/pdb2vn8/pdb
PDB entry 2vn8 coloured by chain, front view.
PDB entry 2vn8 coloured by chain, side view.
PDB entry 2vn8 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Pike ACW, Guo K, Elkins J, Ugochukwu E, Roos AK, Filippakopoulos P, von Delft F, Edwards A, Arrowsmith CH, Weigelt J, Bountra C, Oppermann U

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186762 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Reticulon-4-interacting protein 1, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 375 amino acids
Theoretical weight: 41.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8WWV3 (Residues: 45-396; Coverage: 89%)
Gene names: NIMP, RTN4IP1
Sequence domains:
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand NDP 2 x NDP
Ligand NA 1 x NA
Ligand CIT 1 x CIT
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P3221
Unit cell:
a: 106.95Å b: 106.95Å c: 177.492Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.176 0.175 0.213
Expression system: Escherichia coli BL21(DE3)

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