› 2vna

X-ray diffraction
2.17Å resolution

Structure of Human Zinc-binding Alcohol Dehydrogenase 1 (ZADH1)

Released:
DOI: 10.2210/pdb2vna/pdb
PDB entry 2vna coloured by chain, front view.
PDB entry 2vna coloured by chain, side view.
PDB entry 2vna coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Shafqat N, Kavanagh K, Pike ACW, Muniz JRC, Pilka E, Roos AK, Picaud S, Johansson C, Smee C, Fedorov O, Kochan G, Edwards A, Arrowsmith CH, Weigelt J, Bountra C, von Delft F, Opperman U

Function and Biology Details

Reaction catalysed: 
11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11-alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185435 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prostaglandin reductase 2 Chain: A
Molecule details ›
Chain: A
Length: 357 amino acids
Theoretical weight: 39.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8N8N7 (Residues: 1-350; Coverage: 100%)
Gene names: PTGR2, ZADH1
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand NAP 1 x NAP
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2
Unit cell:
a: 70.335Å b: 83.505Å c: 72.585Å
α: 90° β: 108.43° γ: 90°
R-values:
R R work R free
0.192 0.189 0.226
Expression system: Escherichia coli BL21(DE3)

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