2voh

X-ray diffraction
1.9Å resolution

Structure of mouse A1 bound to the Bak BH3-domain

Released:
Source organism: Mus musculus

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-126662 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bcl-2-related protein A1 Chain: A
Molecule details ›
Chain: A
Length: 157 amino acids
Theoretical weight: 17.92 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q07440 (Residues: 1-152; Coverage: 88%)
Gene names: A1, Bcl2a1, Bcl2a1a, Bfl1
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Structure domains: Blc2-like
Bcl-2 homologous antagonist/killer Chain: B
Molecule details ›
Chain: B
Length: 26 amino acids
Theoretical weight: 2.92 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O08734 (Residues: 65-90; Coverage: 12%)
Gene names: Bak, Bak1

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21
Unit cell:
a: 44.239Å b: 33.255Å c: 58.508Å
α: 90° β: 104.67° γ: 90°
R-values:
R R work R free
0.185 0.182 0.229
Expression system: Escherichia coli BL21(DE3)