› 2vqp

X-ray diffraction
1.6Å resolution

Structure of the matrix protein from human Respiratory Syncytial Virus

Released:
DOI: 10.2210/pdb2vqp/pdb
PDB entry 2vqp coloured by chain, front view.
PDB entry 2vqp coloured by chain, side view.
PDB entry 2vqp coloured by chain, top view.
Source organism: Human respiratory syncytial virus A2
Primary publication:
Surface features of a Mononegavirales matrix protein indicate sites of membrane interaction.
Money VA, McPhee HK, Mosely JA, Sanderson JM, Yeo RP
Proc Natl Acad Sci U S A 106 4441-6 (2009)
PMID: 19251668

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143666 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Matrix protein Chain: A
Molecule details ›
Chain: A
Length: 257 amino acids
Theoretical weight: 28.89 KDa
Source organism: Human respiratory syncytial virus A2
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P0DOE7 (Residues: 1-256; Coverage: 100%)
Gene name: M
Sequence domains: Pneumovirus matrix protein
Structure domains: HRSV-S2 matrix protein, N-terminal domain

Ligands and Environments

3 bound ligands:
Ligand GOL 2 x GOL
Ligand FMT 7 x FMT
Ligand ACT 3 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: C2
Unit cell:
a: 52.299Å b: 78.697Å c: 66.018Å
α: 90° β: 96.28° γ: 90°
R-values:
R R work R free
0.182 0.18 0.217
Expression system: Escherichia coli BL21

Quick links

Citations

15 review citations

Progress in understanding and controlling respiratory syncytial virus: still crazy after all these years.
Collins et al. (2011)
14 more

10 mentions without citation

Paramyxovirus assembly and budding: building particles that transmit infections.
Harrison et al. (2010)
9 more