› 2vrz

X-ray diffraction
1.9Å resolution

Structural analysis of homodimeric staphylococcal aureus EsxA

Released:
DOI: 10.2210/pdb2vrz/pdb
PDB entry 2vrz coloured by chain, front view.
PDB entry 2vrz coloured by chain, side view.
PDB entry 2vrz coloured by chain, top view.
Source organism: Staphylococcus aureus
Primary publication:
Structure of Staphylococcus aureus EsxA suggests a contribution to virulence by action as a transport chaperone and/or adaptor protein.
Sundaramoorthy R, Fyfe PK, Hunter WN
J Mol Biol 383 603-14 (2008)
PMID: 18773907

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189404 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Type VII secretion system extracellular protein A Chains: A, B
Molecule details ›
Chains: A, B
Length: 99 amino acids
Theoretical weight: 11.4 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q99WU4 (Residues: 1-97; Coverage: 100%)
Gene names: SAV0282, esxA
Sequence domains: Proteins of 100 residues with WXG
Structure domains: ESAT-6-like

Ligands and Environments

1 bound ligand:
Ligand ZN 7 x ZN
1 modified residue:
Ligand MSE 6 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P21
Unit cell:
a: 46.232Å b: 27.636Å c: 64.394Å
α: 90° β: 105.43° γ: 90°
R-values:
R R work R free
0.185 0.183 0.223
Expression system: Escherichia coli BL21

Quick links

Citations

8 review citations

ESX/type VII secretion systems and their role in host-pathogen interaction.
Simeone et al. (2009)
7 more

7 mentions without citation

Interbacterial competition mediated by the type VIIb secretion system.
Boardman et al. (2023)
6 more