› 2vwi

X-ray diffraction
2.15Å resolution

Structure of the OSR1 kinase, a hypertension drug target

Released:
DOI: 10.2210/pdb2vwi/pdb
PDB entry 2vwi coloured by chain, front view.
PDB entry 2vwi coloured by chain, side view.
PDB entry 2vwi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the OSR1 kinase, a hypertension drug target.
Villa F, Deak M, Alessi DR, van Aalten DM
Proteins 73 1082-7 (2008)
PMID: 18831043

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132009 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase OSR1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 303 amino acids
Theoretical weight: 34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O95747 (Residues: 1-303; Coverage: 58%)
Gene names: KIAA1101, OSR1, OXSR1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand AU 11 x AU
Ligand ANP 4 x ANP
Ligand MG 3 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P212121
Unit cell:
a: 74.13Å b: 99.9Å c: 158.525Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.253 0.253 0.287
Expression system: Escherichia coli BL21

Quick links

Citations

4 review citations

Germinal center kinases in immune regulation.
Yin et al. (2012)
3 more

7 mentions without citation

Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport.
Gagnon et al. (2012)
6 more