› 2vy4

Solution NMR

U11-48K CHHC ZN-FINGER DOMAIN

Released:
DOI: 10.2210/pdb2vy4/pdb
PDB entry 2vy4 coloured by chain, ensemble of 20 models, front view.
PDB entry 2vy4 coloured by chain, ensemble of 20 models, side view.
PDB entry 2vy4 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the U11-48K CHHC zinc-finger domain that specifically binds the 5' splice site of U12-type introns.
Tidow H, Andreeva A, Rutherford TJ, Fersht AR
Structure 17 294-302 (2009)
PMID: 19217400

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179757 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
U11/U12 small nuclear ribonucleoprotein 48 kDa protein Chain: A
Molecule details ›
Chain: A
Length: 37 amino acids
Theoretical weight: 4.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q6IEG0 (Residues: 53-87; Coverage: 10%)
Gene names: C6orf151, SNRNP48
Sequence domains: U11-48K-like CHHC zinc finger

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

The significant other: splicing by the minor spliceosome.
Turunen et al. (2013)
4 more

2 mentions without citation

Conservation of the three-dimensional structure in non-homologous or unrelated proteins.
Sousounis et al. (2012)
1 more