› 2vyi

X-ray diffraction
2.4Å resolution

Crystal Structure of the TPR domain of Human SGT

Released:
DOI: 10.2210/pdb2vyi/pdb
PDB entry 2vyi coloured by chain, front view.
PDB entry 2vyi coloured by chain, side view.
PDB entry 2vyi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional characterization of human SGT and its interaction with Vpu of the human immunodeficiency virus type 1.
Dutta S, Tan YJ
Biochemistry 47 10123-31 (2008)
PMID: 18759457

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129105 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Small glutamine-rich tetratricopeptide repeat-containing protein alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 131 amino acids
Theoretical weight: 14.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O43765 (Residues: 84-210; Coverage: 41%)
Gene names: SGT, SGT1, SGTA
Sequence domains:
Structure domains: Tetratricopeptide repeat domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P21212
Unit cell:
a: 67.823Å b: 81.939Å c: 55.923Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.187 0.249
Expression system: Escherichia coli BL21

Quick links

Citations

4 review citations

Versatile TPR domains accommodate different modes of target protein recognition and function.
Allan et al. (2011)
3 more

13 mentions without citation

Structural and Functional Insights into Small, Glutamine-Rich, Tetratricopeptide Repeat Protein Alpha.
Roberts et al. (2015)
12 more